Clinical Features, Laboratory Findings Outcomes in Multisystem Inflammatory Syndrome (Mis-C) Following Covid-19 Infection - a Multicenter, Observational, Ambidirectional Cohort Study in Rio De Janeiro State, Brazil

Objectives: As of March 5th, 2022, around 1.585 cases of MIS-C and 98 deaths (6,4%) were reported in Brazil. The state of Rio de Janeiro State (RJ) having 94 cases (5,9%) and 4 deaths (4,2%)1.Our aim was to evaluate clinical and laboratory features, and management of MIS-C in seven pediatric hospitals in RJ, Brazil. Method(s): Multicenter, observational, ambidirectional cohort study in seven tertiary hospitals in RJ(Brazil), assessing medical charts of pediatric inpatients (0-18 years) diagnosed with MIS-C according to WHO/CDC criteria, from August, 2020 to February, 2022. Descriptive statistics were used to analyze distributions of continuous variables, frequencies, and proportions. Result(s): A total of 112 cases of MIS-C were enrolled. The mean age was 4.2 years and thre was male predominance (59,8%). All cases had a SARS-CoV-2 contact (29.5% close contact;31.3%:positive PCR;serology:43.8%).Only 12.5% had comorbidities. Length of stay (LOS) was 7 days.Median duration of fever was 8 days. Most common symptoms were: rash(67%);gastrointestinal (67%);conjunctivitis (42%);neurological(39.6%);cardiovascular(37.5%);cervical lymphadenopathy (36.6%), and shock/hypotension(28.6%).Co-infection occurred in 3 patients. Forty-four patients fulfilled criteria for Kawasaki disease. Most patients were admitted to PICU(12;62,5%) for amedian of 2 days. Respiratory distress was seen in 18,7%;hypotension:28,6%, and shock in 23,2%. Main laboratory findings were: high C-reactive protein in 95%;D-dimer:77%, anemia:77%, thrombocytosis:63%;transaminitis:43.8%, lymphopenia:38%;hypoalbuminemia:34%;thrombocytopenia: 29%;hypertriglyceridemia:28%, and high pro-BNP in 27%. Echocardiogram was performed in 91/112 patients;abnormal in 70,3%;exhibiting myocardial dysfunction( 25%);pericardial effusion(21%);coronary dilation/aneurysms(11%) and, valvulitis (14.5%). IVIG+corticosteroids (CTC) were administered in 59.8%(67/ 112);18.6%(18/112) IVIG only;10.7%(12/112) CTC only;3.4%(4/112)biologics, and 15(13.3%) received no treatment. ASA low dose in 77.7% (87/112) and moderate/high dose in 34.8%. Oxygen support was needed in 27,7%;vasoactive amines:18,7%;dialysis:5,3%, and transfusion:18,7%.One patient died from a cytokine storm syndrome. Conclusion(s): Our study reports a higher number of MIS-C cases in RJ than the number reported to Brazilian authorities, highlighting underreporting. Our patients were younger, had fewer comorbidities, cardiovascular/gastrointestinal/renal involvement, shortest LOS in ICU, and a higher frequency of myopericarditis.

Learning from crisis: repurposing to address grand challenges

We highlight that institutions may encourage or discourage organizations to engage in the repurposing of technologies and value chain linkages for attaining financial goals and responding to social needs and challenges. Based on evidence from several examples of repurposing and collective action during the recent COVID-19 health crisis, we try to learn and infer, how institutions can create an environment that fosters repurposing beyond crisis situations. Our evidence, accordant to Chris Freeman's argument on the success of nations to catch up and maintain technological and trade competitiveness, suggest that multiple institutional factors may influence a country's ability to design and implement solutions through technological repurposing. We discuss the implications of this result and future research directions. © 2021 Informa UK Limited, trading as Taylor & Francis Group.

Chronic diseases and religiosity/spirituality during the early stages of the COVID-19 pandemic

Religiosity and spirituality have been studied as resources for coping with crisis and social disruption. This study investigates religiosity/spirituality as a potential protective resource against the emotional impact of the COVID-19 pandemic in individuals diagnosed with malignant and non-malignant chronic diseases. This is a cross-sectional, descriptive-exploratory study, with a quanti-qualitative approach. The convenience sample was composed of 78 individuals, divided into two groups. An online form was used. The data from the close-ended questions were tabulated using descriptive statistics. The content of the open-ended questions was examined qualitatively by thematic analysis. The two groups showed signs of emotional distress at similar levels and expressed increased faith and belief that future gains should come from the current distress. Individuals with life-threatening diseases expressed intensified spirituality. Faith was highlighted by participants as a resource to face the challenges of this dramatic period and should be valued by health care teams. © 2022, Pontificia Universidade Catolica de Campinas. All rights reserved.